Erdosteine
نویسندگان
چکیده
منابع مشابه
Erdosteine Therapy for Renal Failure: Current Perspectives
I read the recently published paper of Ebru Uz et al. (1), in the Nephro-Urology Monthly which focused on the renoprotective effects of erdosteine when it is used for cyclosporine-A (CsA) induced chronic nephrotoxicity. Erdosteine belongs to the class of mucolytics which is used for the treatment of wet cough and chronic obstructive pulmonary disease (CoPD). It has been reported that erdosteine...
متن کاملEffect of Erdosteine on Cyclosporine Induced Chronic Nephrotoxicity
Drugs and exogenous toxins, including aminoglyco-sides, amphotericin B, cisplatin, and radiocontrast media , may cause acute kidney injury (1). The manifestations which indicate that damage is occurring are a sudden increase in kidney injury biomarkers (NGAL [neutrophil gelatinase-associated lipocalin], KIM-1 [kidney injury molecule-1], etc.) and kidney failure (creatinine, cystatin C). This im...
متن کاملErdosteine Modulates Hepatotoxic Effect on Rats Treated with Cisplatin
Cisplatin (CP) is a widly used anticancer drug against abroad spectrum of malignance, but at high dose, it can produce undesirable effects such as hepatotoxicity. The aim of this study was to investigate the possible protective effect of erdosteine (Erd) against CP-induced biochemical, histopathological changes and hepatotoxicity associated with oxidative stress and inflammatory changes in male...
متن کاملAntioxidant and antiapoptotic effects of erdosteine in a rat model of ovarian ischemia-reperfusion injury
OBJECTIVES To evaluate the protective effect of erdosteine, an antiapoptotic and antioxidant agent, on torsion-detorsion evoked histopathological changes in experimental ovarian ischemia-reperfusion (IR) injury. MATERIALS AND METHODS Eighteen female Wistar albino rats were used in control, IR, and IR+Edosteine (IR-E) groups, (n=6 in each). The IR-E group received the erdosteine for seven days...
متن کاملPharmacology and clinical efficacy of erdosteine in chronic obstructive pulmonary disease.
Erdosteine is a multimechanism, mucolytic agent that decreases the sputum viscoelastic properties and bacterial adhesion to the cell membrane, endowed with bronchial anti-inflammatory activity and a scavenging effect on free oxidant radicals. Erdosteine is a prodrug and metabolite I is the active metabolite of erdosteine owing to its free thiol group. In acute infective exacerbation of chronic ...
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ژورنال
عنوان ژورنال: Drugs
سال: 1996
ISSN: 0012-6667
DOI: 10.2165/00003495-199652060-00011